EXPERIENCE OF PHARMACOGENETIC TESTING IN THE TREATMENT OF ANTIPSYCHOTICS

Introduction One of the promising methods for optimizing treatment in order to achieve high-quality remissions is a personalized approach prescribing therapy form pharmacogenetic testing, feasibility which has already been substantiated and proven number clinical guidelines. By beginning 2022, several influential regulatory expert organizations recommend considering results genetic testing when therapy. Thus, personalization antipsychotic being introduced world practice. Objectives To establish significance markers that determine efficacy safety patients with schizophrenia Methods The study included 264 (141 men, 123 women; 27.3 ± 4.5 years) from among first hospitalized psychiatric hospital period 2018-2020, meeting inclusion criteria (psychosis within spectrum disorders; consent participate research). Non-inclusion - signs organic brain damage; alcohol or substance abuse; somatic pathology stage decompensation). examination took place three stages days hospitalization at peak acute condition during formation remission after 6 12 months. Genetic analysis was performed using high-density biochips Illumina CoreExome Bead (Illumina Inc, USA). During follow-up observation, some dropped out due refusal undergo examination, change diagnosis residence. After months, it possible trace dynamics state 91 (50 41 24.9 4.6 years). Results Based on results, two types were identified relatively favorable unfavorable course. stable corresponding proposed by working group noted 47 (51.6%), carriers gene polymorphisms: DRD2 rs1799732 (del); COMT rs4680(GG); BDNF rs6265 (CC); ANKK1 rs1800497 (GG); MC4R rs489693 (AA); ABCB1 rs1045642 ABCC1 rs212090 (GG). An course ineffectiveness antipsychotics found 48.4% cases (G/del) carriers; rs4680(AA); (TT); (AA). Conclusions analyzing dynamic characteristics schizophrenia, we can talk about relationship between establishment presence polymorphisms genotype, whose role terms effectiveness antipsychotics. Disclosure Interest None Declared